BIOACTIVE COMPOUND AND NUTRITIONAL INTERVENTION OF CORONAVIRUS-19 PATIENTS

Abstract

The data presented in this review article is aimed to support research on COVID- 19, the symptoms, transmission, prevention, and immune boasting methods against this deadly virus.It is need of time to search for alternative treatment methods to control the spread of COVID-19. Traditional food and medicinal plants contain a large number of ingredients which can increase the immunity in addition to their antiviral properties. Nutritional intervention such as vitamin A, B, C, D and E help to strengthen immune system. The Omega-3 polyunsaturated fatty acids are important mediators of the adaptive immune responses and precursors of the resolvins/prolactin, leukotriene and prostaglandin respectively. Minerals such as, zinc, selenium and iron are important for the development and maintenance of immune cells of innate and adoptive immune system. Bioactive intervention including polyphenolic compound including myricetin, scutellarein, quercetin, silvestrol, caffeic acid display reasonable levels of inhibition activity of COVID-19 helicase and Silvestrol subclass of flavonoid prevented the translation of HCoV-229E proteins specific RNA helicase. Alkaloid such as, tetrandrine, fangchinoline,cepharanthine and tryptanthrin have anti-inflammatory, immunologic and anti-allergic effects and Tryptanthrin subclass of alkaloid is effective in inhibiting the early and late stages of the HCoV-NL63 replication and blockage of post entry of HCoV replication. Terpenoid such as Saikosaponin inhibits the viral penetration and attachment. Protein such as lecithin and Griffithsin are the most important inhibitors of MERS-CoV. The decoction of Syzgium Aromaticum, Zingiberofficinale Roscoe, Piper nigrum linn, Sudarshana Ghana vati, Curcuma longa, Chauvan prasha participate in various processes of the adaptive/innate immunity. Dietary food supplements such as citrus fruits(orange, lemon, grapes), apple, sitaphal, papaya, green leafy vegetable such as, broccoli, garlic, onion; ginger, nuts, pepper, turmeric, egg yolk, mushroom, shellfishare good for fighting against various diseases.