Association of Vitamin D Deficiency with Hypothyroidism

Abstract

Background: The main function of vitamin D is to regulate bone metabolism, although its position as an immunological modulator has lately been highlighted. Over the last few years, evidence has accumulated that vitamin D has a crucial role in the prevention of autoimmune disorders. However, there is no solid evidence that it has a role in non-autoimmune thyroid illness. Objective: The primary objective of this study is to assess the link between vitamin D deficiency and hypothyroidism in patients at tertiary care hospital. Methodology: This was prospective cross-sectional study, conducted at Department of Pathology, Chandika Medical College, Larkana for a period of one year. The levels of serum vitamin D (25-OH) were tested in 47 healthy people and 47 hypothyroid patients. Vitamin D insufficiency was defined as a concentration of less than 10 ng/ml. Results: Serum 25(OH) vitamin D levels in hypothyroid patients were substantially higher than in controls (t=11.1, p = 0.003). Female patients had a lower level of it than male patients (t=0.383, p=.712). Conclusion: A significant association was found between vitamin D deficiency and hypothyroidism in patients as compared to healthy controls, making it important investigation to be performed in routine patients with hypothyroidism.